Description: Halofuginone hydrobromide is a quinazolinone derivative related to the antimalarial drug febrifuginone. It was originally extracted from leafs and roots of the traditional Chinese herbal Cichroa febrifuga plant, which is used traditionally in Chinese medicine to treat malaria.

Origin: A synthetic derivative of an alkaloid originally isolated from an asiatic plant, Dichroa febrifuga Lour.

Chemical structure:

Dosage: 2-3 mg/kg active substance

Mode of Action: Acts especially on the 1st generation of schizonts early after sporozoite invasion. Coccidiocidal activity against E. tenella & E. maxima, coccidiostatic activity against E. acervulina.

Stage of the life cycle affected by the drug: It is effective against asexual stages of most speciesof Eimeria, delaying development.

Comments: Halofuginone decreased skin collagen. Continuous feeding of the anticoccidial halofuginone to broilers is associated with reduced skin tensile strength and increased skin tearing during processing (Granot, I., et al. Poultry Science 70.7 (1991): 1559-1563).