Description: Diclazuril is a synthetic compound of the triazines group (2,6-Dichloro-α-(4-chlorophenyl)-4-(4,5- dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)- benzeneacetonitrile) a benzeneacetonitrile derivative used for the control of coccidiosis poultry.
Chemical Formula: C17H9Cl3N4O2
Stage of the life cycle affected by the drug: By disrupting both the asexual (schizogony) and sexual (gametogony) stages of development, it effectively halts intracellular replication. This blocks the excretion of oocysts into the environment and cleanly breaks the parasite's transmission cycle.
Dosage: 1 ppm.
Pahrmacokinetics: The drug is absorbed relatively slowly, reaching peak plasma concentrations ($T_{max}$) between 6 hours (poultry) and 24 hours (ruminants and horses). It undergoes very limited hepatic biotransformation. Up to 90% of the active compound is excreted completely unchanged, primarily through the feces.
Toxicity: Diclazuril possesses an excellent safety profile with an exceptionally high therapeutic index.
Incompatibilities & Drug interactions: None Known.