Description: Pyridinols
Dosage: 125 ppm
Mode of Action: Inhibit mitochondrial energy production in sporozoites and trophozoites - early stages of Eimeria development.
Stage of life cycle affected by the drug: Active against the sporozoite stage of Eimeria (day 1-2). Coccidiostatic.
Pharmacokinetics: Rapidly absorbed and excreted in the urine following oral administration.
Toxicity: clopidol exhibits low acute toxicity; Chicken LD50 >8.0 g/kg; Turkey: LD50 2.5 g/kg
Residues: The highest concentrations of clopidol are typically detected in the kidney and liver tissues. Clopidol accumulated primarily in eggs rather than the other edible tissues.
Incompatibilities and interactions: A synergistic combination of clopidol and methyl-benzoquate provides a slight improvement over the individual drugs.
Comments: Weak against E. acervulina.
