IB: Vaccine recombinants and chicken-selected subpopulation
A new study discusses the emergence of novel variants of the infectious bronchitis virus (IBV) as a result of vaccine subpopulation selection and recombination events between vaccine and field strains. According to this study, vaccine subpopulations play a significant role in the emergence of novel variants of IBV by contributing to the selection of virulent viruses through recombination events and mutations. These factors lead to continuous disease outbreaks in poultry, causing economic losses in the industry. Alternative technologies, such as new vaccine platforms or approaches, are necessary to replace live attenuated vaccines. Potential replacement technologies may include recombinant vaccines, subunit vaccines, vector vaccines, or nucleic acid-based vaccines. These technologies aim to provide safer and more effective alternatives to live attenuated vaccines in preventing infectious diseases in poultry.
