HPAI H7N9 virus evolution amid vaccination
A new study by a Chinese research group, published in Emerging Microbes & Infections, delves into the evolution of the H7N9 highly pathogenic avian influenza virus within the context of vaccination, offering valuable insights into the genetic and biological changes of the virus in response to vaccination efforts. The study observes a gradual shift in the receptor-binding preference of H7N9 viruses in poultry, indicating an increased affinity for avian-type receptors and a decreased affinity for human-type receptors. Furthermore, the study finds that vaccination prevents reassortment with other viruses, thereby slowing the evolution of the virus.
According to the authors, these findings suggest that vaccination plays a crucial role in shaping the evolution of the H7N9 virus, reducing its potential threat to human populations by eliminating its ability to bind to human-type receptors. The study underscores the importance of continuous genetic monitoring and enhancing vaccine efficacy to control highly pathogenic avian influenza (HPAI) viruses.
China's extensive experience in avian influenza vaccines, along with its success in reducing the spread of the H7N9 virus and human incidence, warrants greater attention from poultry experts in countries that consider themselves 'advanced.' Meanwhile, they grapple with a virus that continues to spread, evolve, and pose significant challenges in both wildlife and commercial animal sectors.
