Salmonella infection outcomes in relation to isolate resistance
According to a study published in Clinical Infectious Diseases by researchers from the Centers for Disease Control and Prevention (CDC), infections caused by antibiotic-resistant strains of Salmonella are linked to more severe clinical outcomes, such as hospitalization and mortality. The study involved an analysis of epidemiological data sourced from the Foodborne Diseases Active Surveillance Network (FoodNet) and antimicrobial resistance information from the National Antimicrobial Resistance Monitoring System (NARMS). The research, conducted by the CDC's Division of Foodborne, Waterborne, and Environmental Diseases, investigated the outcomes of individuals with non-typhoidal Salmonella infections spanning from 2004 to 2018. The researchers compared the clinical results of patients with Salmonella infections resistant to antibiotics to those caused by non-resistant strains, while adjusting for variables like age, location, racial or ethnic background, international travel history, association with outbreaks, and the specific serotype or source of the Salmonella isolate.
The findings revealed that patients whose Salmonella isolates displayed antibiotic resistance were more likely to be admitted to a hospital (31% compared to 28%) or require a hospital stay lasting three days or longer (20% compared to 16%) in comparison to patients with isolates that were not resistant to antibiotics. Although fatalities were uncommon, they were more frequent among individuals infected with antibiotic-resistant Salmonella (1.0% compared to 0.4%).
