Description: Flubendazole
Mechanism of action: Benzimidazoles interrupt parasite energy metabolism by binding to tubulin, thereby disrupting microtubular cell structure and preventing nutrient uptake and other functions.
Indications: broad-spectrum nematicide and taenicide anthelmintic
Dosage: 30 mg/kg feed × 7 days in poultry; 60 mg/kg feed × 7–14 days in partridges, pheasants.
Pharmacokinetics: Flubendazole is almost insoluble in water. Orally administered flubendazole is poorly absorbed into the bloodstream. This means that significant amounts remain in the gastrointestinal tract and are available for the control of gut-dwelling roundworms and tapeworms.
Metabolism:
Toxicity: Oral LD50, rat, acute: >5000 mg/kg
Residues: In layers, flubendazole leaves very low residues in eggs, which allows low or nil withholding periods for eggs. Data from Kan et al., (1998) Analyst, 123:2525–2527
