Fluralaner is an isoxazoline compound. Fluralaner is a systemic acaricide and insecticide. It inhibits the GABA and L-glutamate receptors located at the central nervous and peripheral neuromuscular system (chloride channels). No resistance and cross resistance with any currently used drugs have been reported and the wide safety margin has been demonstrated in dogs and poultry. Fluralaner does not affect reproductive performance in chickens. The use of fluralaner in pullets, breeders, and layer hens is approved to treat Dermanyssus gallinae in Europe and Australia with a dosage regimen 0.5 mg/kg twice, 7 d apart, via drinking water, and having egg and meat withholding times of 0 and 14 days, respectively.
The mite-killing activity of fluralaner is evident within 4 h of the first administration and is maintained for at least the next 14 days. Adult mites are killed quickly, while any egg or non-feeding larvae present at the time of treatment are subsequently killed as they mature to nymphs and take a blood meal, with mite populations reported to decline by as much as 99% within 3 days of the first fluralaner administration and up to 100% within 2 days of the second administration.
Molecular Formula: C22H17Cl2F6N3O3
