Marek’s disease-like viruses

Marek’s disease-like viruses

Gallid herpesvirus 2, Marek’s disease virus serotype 1


 Year  Event  Reference


Jozsef Marek first publishes his observations of a paralytic disease affecting 4 cocks

Marek J (1907) Dtsch Tierärztl Wochenschr



The agent of Marek’s Disease is discovered to be a herpesvirus

Churchill AE, Biggs PM (1967) Nature 215:528-530


First successful vaccine against a herpesviral disease and additonally, the first vaccine against a malignancy

Churchill AE, et al. (1969) Nature 221:744-747


The first isolation of Herpesvirus of turkeys

Kawamura H, et al. (1969) Avian Dis 13:853-863


The biological source of cell-free, enveloped virions  is demonstrated to be the feather follicle epithelium

Calnek BW, et al. (1970) Avian Dis 14:219-333


Herpesvirus of Turkeys is shown to function as a vaccine against Marek’s Disease

Okazaki W, et al. (1970) Avian Dis 14:413-429


Genetic analysis of MDV and HVT lead to their reclassification as alphaherpesviruses

Buckmaster AD, et al. (1988) J Gen Virol 69:2033-2042


First reported isolation of a recombinant Marek’s Disease Virus expressing a heterologous gene

Cantello J, et al. (1991) J Virol 65:1584-1588


REV, an avian retrovirus integrates into MDV DNA; first report of retroviral integration into a herpesvirus

Isofort R, et al. (1992) Proc Natl Acad Sci 89(3) :991-995