Gallid herpesvirus 2, Marek’s disease virus serotype 1
Year | Event | Reference |
1907 |
Jozsef Marek first publishes his observations of a paralytic disease affecting 4 cocks |
Marek J (1907) Dtsch Tierärztl Wochenschr 15:417-421 |
1967 |
The agent of Marek’s Disease is discovered to be a herpesvirus |
Churchill AE, Biggs PM (1967) Nature 215:528-530 |
1969 |
First successful vaccine against a herpesviral disease and additonally, the first vaccine against a malignancy |
Churchill AE, et al. (1969) Nature 221:744-747 |
1969 |
The first isolation of Herpesvirus of turkeys |
Kawamura H, et al. (1969) Avian Dis 13:853-863 |
1970 |
The biological source of cell-free, enveloped virions is demonstrated to be the feather follicle epithelium |
Calnek BW, et al. (1970) Avian Dis 14:219-333 |
1970 |
Herpesvirus of Turkeys is shown to function as a vaccine against Marek’s Disease |
Okazaki W, et al. (1970) Avian Dis 14:413-429 |
1988 |
Genetic analysis of MDV and HVT lead to their reclassification as alphaherpesviruses |
Buckmaster AD, et al. (1988) J Gen Virol 69:2033-2042 |
1991 |
First reported isolation of a recombinant Marek’s Disease Virus expressing a heterologous gene |
Cantello J, et al. (1991) J Virol 65:1584-1588 |
1992 |
REV, an avian retrovirus integrates into MDV DNA; first report of retroviral integration into a herpesvirus |
Isofort R, et al. (1992) Proc Natl Acad Sci 89(3) :991-995 |