Infectious Diseases 2022

Infectious Diseases 2022

A synergistic effect between MDV and REV

Front Vet Sci . 2022 Mar 22 21 April, 2022

Coinfection of viruses generally influences the disease pattern compared with a single infection. The outcome of coinfection usually is viral interference. Besides interference, coinfections of viruses may also enhance viral replication and virulence. Coinfection with Marek's disease virus (MDV) and reticuloendotheliosis virus (REV) causes synergistic pathogenic effects and serious losses to the poultry industry.
A new study found that coinfection of MDV and REV significantly increased the expression levels of both the viral gene transcript and virus titers. Furthermore, MDV and REV could infect the same cells and synergistically induce cytopathy.