Decoquinate

Decoquinate

Description:

Decoquinate is a chemically synthesized 4-hydroxyquinolone. Decoquinate is a potent quinolone anticoccidial drug for the prevention of avian coccidiosis with a primary static effect on sporozoites and a secondary cidal effect on early schizonts.

 

Mode of Action:

Decoquinate acts by arresting the development of sporozoites following their penetration of the gut epithelium. Decoquinate significantly inhibited mitochondrial respiration and electron transport in Eimeria parasites. However, the mechanism of toxicity is not known.

 

Dosage:

30 ppm

Toxicity:

Rat LD50 > 5000 mg/kg bw

Drug Interactions:

 

 

Pharmacokinetics:
Rapid emergence of resistance to this compound
and others as buquinolate and nequinate has been
their major weakness.
Decoquinate is only absorbed to a small extent from the gastrointestinal tract of chicken, and once absorbed, is rapidly cleared from blood and tissues via bile and to a much lesser extent in urine.Decoquinate is distributed widely in tissues. Skin/fat is the target tissue.
 

Resistance:

Rapid emergence of resistance to this compoundand others as buquinolate and nequinate has beentheir major weakness.