Infectious Diseases 2019

Infectious Diseases 2019

Why S. Infantis is less invasive than S. Typhimurium?

J Infect Dis. 2019 25 May, 2019

Salmonella enterica serovar Infantis is one of the ubiquitous serovars of the bacterial pathogen Salmonella enterica and recently has been emerging in many countries worldwide. Nonetheless, not much is known about S. Infantis epidemiology, host-adaptation and virulence. Moreover, while S. Infantis adheres better to host cells and highly colonizes mouse intestines at early time post-infection, it is significantly less invasive and induces much lower inflammation and pathology in-vivo than S. Typhimurium. A group of Israeli and German researchers demonstrate that these differences were associated with lower expression of the SPI-1 regulon and this contribute to epidemiological and virulence variation between genetically similar non-typhoidal Salmonella serovars.