Infectious Diseases 2007

Infectious Diseases 2007

Egypt: Tamiflu resistant avian influenza virus

Egypt 18 January, 2007 Viruses with a genetic mutation, linked in laboratory testing to moderately reduced susceptibility to oseltamivir, have been discovered in two persons previously reported with H5N1 infections in Egypt. WHO announced that genetic sequencing had found the N294S change in the isolates (an asparagine, N, to serine, S, mutation at position 294). Both patients had been on treatment with oseltamivir for two days before the clinical samples that yielded the viruses were taken.
The two patients from whom samples were taken were a 16 year-old female and a 26 year-old male from Gharbiyah Province, Egypt (The ages and dates in this update related to the two patients, may differ slightly from earlier reports, but reflect the most recent information provided to WHO).
They were a niece and uncle, respectively, who lived in the same house. The girl was admitted to a hospital on 19 December 2006, while the man was admitted on 17 December. On 21 December they began receiving 2 tablets per day of oseltamivir. On 23 December they were moved to a referral hospital. The samples which have so far been tested were taken from the two patients on 23 December. The girl died on 25 December and the man died on 28 December 2006 (WHO - See: The New England Journal of Medicine 2005, 2636-2667).