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Marek’s disease-like viruses

Gallid herpesvirus 2, Marek’s disease virus serotype 1

 

 

 Year  Event  Reference

1907

Jףzsef Marek first publishes his observations of a

paralytic disease affecting 4 cocks

Marek J (1907) Dtsch Tierהrztl Wochenschr

15:417-421

1967

The agent of Marek’s Disease is discovered to be a

herpesvirus

Churchill AE, Biggs PM (1967) Nature 215:528-530

1969

First successful vaccine against a herpesviral

disease and additonally, the first vaccine against a

malignancy

Churchill AE, et al. (1969) Nature 221:744-747

1969

The first isolation of Herpesvirus of turkeys

Kawamura H, et al. (1969) Avian Dis 13:853-863

1970

The biological source of cell-free, enveloped virions

is demonstrated to be the feather follicle epithelium

Calnek BW, et al. (1970) Avian Dis 14:219-333

1970

Herpesvirus of Turkeys is shown to function as a

vaccine against Marek’s Disease

Okazaki W, et al. (1970) Avian Dis 14:413-429

1988

Genetic analysis of MDV and HVT lead to their

reclassification as alphaherpesviruses

Buckmaster AD, et al. (1988) J Gen Virol 69:2033-2042

1991

First reported isolation of a recombinant Marek’s

Disease Virus expressing a heterologous gene 

Cantello J, et al. (1991) J Virol 65:1584-1588

1992

REV, an avian retrovirus integrates into MDV DNA;

first report of retroviral integration into a herpesvirus

Isofort R, et al. (1992) Proc Natl Acad Sci 89(3) :991-995


 
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