Lasalocid

Lasalocid

Description:

A polyether divalent carboxylic ionophore. Lasalocid is an anticoccidial feed additive. It is indicated for use for the control of coccidiosis in broilers, chickens reared for laying and turkeys.

 

Origin:

Fermentation of Streptomyces lasaliensis; a mixture of several closely related homologues: A, B, C, D and E. Lasalocid homologues B, C, D and E make up no more than a total of 10% of the total weight of the active substance.

 

Mechanism of action:

The mechanism of action of lasalocid and other ionophores has been extensively investigated and reported. Like other carboxylic polyether ionophores, lasalocid disturbs ionic homeostasis, leading to osmotic lysis of coccidia.

Dosage:

90-125 ppm

 

Pharmacokinetics:
Following oral administration to poultry species, lasalocid sodium is rapidly absorbed and
detected in the peripheral circulation. Peak concentrations in blood are observed within two
hours, with a half-life of three hours. Distribution is widespread and rapid with lasalocid
detected in all edible tissues. Metabolism in each tissue is significant, with 5–7 unidentified
polar metabolites produced. Excretion of the parent moiety and metabolites is rapid and
primarily via the faeces

Following oral administration to poultry species, lasalocid sodium is rapidly absorbed and detected in the peripheral circulation. Peak concentrations in blood are observed within two hours, with a half-life of three hours. Distribution is wide spread and rapid with lasalocid detected in all edible tissues. Metabolism in each tissue is significant, with 5–7 unidentified polar metabolites produced. Excretion of the parent moiety and metabolites is rapid and primarily via the faeces.

Toxicity:

Mice LD50 146 mg/kg BW; Rat LD50 122 mg/kg BW; Chickens 71.5 mg/kg BW; Horses 15 mg/kg BW;  

 

Incompatibilities and interactions:

Clinically important interactions between ionophore anticoccidials and the antibiotic tiamulin (and other antibiotics) are well known phenomena in chickens, turkeys and other species. Avoid concurrent administration of lasalocid with tiamulin. Avoid concurrent administration of lasalocid with chloramphenicol.

 

Comments:  Causes excess water excretion and wet litter.